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GBS | CIDP Foundation India

Intro to Guillain-Barré Syndrome (GBS)

GBS is rare, serious, and often sudden, but you don’t have to navigate it alone. Here, you can better understand what it means for you or someone you love and discover support, treatments, and insights

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What is Guillain-Barré Syndrome (GBS)?

Guillain-Barré (Ghee-yan Bah-ray) Syndrome is an inflammatory disorder of the peripheral nerves outside the brain and spinal cord.

It’s also called:

  • Acute Inflammatory Demyelinating Polyneuropathy
  • Landry's Ascending Paralysis

GBS is characterized by the rapid onset of numbness, weakness, and often paralysis of the legs, arms, breathing muscles, and face. Paralysis is ascending, meaning that it travels up the limbs from fingers and toes towards the torso. Loss of reflexes, such as the knee jerk, are usually found.

Read the Intro Booklet

Frequently Asked Questions

Explore answers to common questions about symptoms, treatment, recovery, and what to expect at every stage of the journey.

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  • GBS occurs when your immune system mistakenly attacks your healthy peripheral nerves, damaging their protective myelin sheath.
  • This damage disrupts nerve signals to the brain, leading to weakness, numbness, and paralysis.
What causes GBS?
  • The exact cause is unknown, but it often follows a viral or bacterial infection (like Campylobacter, flu, COVID-19, Zika) due to “molecular mimicry” where infection-fighting antibodies attack nerve cells.
  • Rarely, surgery or vaccinations can trigger it.
Who gets GBS?

Anyone can get it, but it's more common in adults over 50, and slightly more in men.

What are the symptoms?
  • Early: Tingling and weakness, often starting in both legs and spreading upwards.
  • Progression: Can rapidly worsen over days to weeks, affecting arms, face, and breathing muscles.
  • Severe: Paralysis, difficulty breathing, swallowing, speaking, and autonomic issues (blood pressure, heart rate).
Is it contagious?

No, GBS is not contagious.

How is it diagnosed?

Doctors use physical exams, nerve conduction studies (electromyography – EMG), and a spinal tap (lumbar puncture) to analyze spinal fluid.

How is it treated and what's the outlook?
  • Treatment: Hospitalization is needed; treatments like IV immunoglobulin or plasmapheresis help.
  • Recovery: Most start improving in 2-4 weeks, but full recovery takes months to years, requiring physical therapy.
  • Prognosis: Most recover, but many experience some level of residual effect including but not limited to: weakness, numbness, or fatigue.
When to seek emergency care (Call 911/Emergency Services)

If you experience sudden, rapid weakness, tingling, or paralysis, especially if you have trouble breathing or swallowing.

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Source: GBS | CIDP Foundation International (educational content).

Medical disclaimer

This website provides educational information and is not a substitute for medical advice, diagnosis or treatment. Always discuss your individual situation with a qualified doctor.